How is neurofibromatosis type 2 different from type 1?
The gene for NF-2 is on chromosome 22, as opposed to chromosome 17 for NF-1. NF-2 tumors can be remembered with the mnemonic MISME , which stands for M ultiple I nherited S chwannomas, M eningiomas, and E pendymomas. Classically, these appear as bilateral cerebellopontine angle tumors, representing bilateral vestibular schwannomas, which are diagnostic of NF-2, but may involve any of the cranial nerves.
