What is the treatment for BK associated nephropathy?
The goal in treating BK-associated nephropathy is to eradicate the virus while maintaining kidney function and preventing acute or chronic rejection. Most treatments of BK-associated nephropathy involve reducing immunosuppression to permit native, immune-mediated handling of the BK virus. Possible strategies include discontinuation of a single immunosuppressive agent, reduction of dosages, and steroid avoidance. Antiviral therapy with leflunomide or cidofovir has been used in conjunction with decreasing immunosuppressants in some instances. IVIG also has been used, particularly in patients with concomitant acute rejection.