Kidney biopsy findings in BK associated nephropathy

Kidney biopsy findings in BK associated nephropathy

What does the kidney biopsy show in BK associated nephropathy?

Biopsy remains the gold standard for the diagnosis of BK-associated nephropathy.

BK virus can induce a number of characteristic changes on kidney biopsy, including intranuclear viral inclusions, tubular injury/tubulitis, and tubulointerstitial inflammation.

Because none of these kidney biopsy findings are pathognomonic for BK-associated nephropathy, the diagnosis must be confirmed by demonstrating antibodies against BK with immunohistochemistry.

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