How high prolactin result in gonadal dysfunction? What are the symptoms associated with gonadal dysfunction?
Elevated prolactin levels suppress the hypothalamic–pituitary–gonadal axis primarily by interfering with the secretion of gonadotropin-releasing hormone in the hypothalamus, resulting in decreased circulating levels of gonadotropins and estrogen or testosterone. Symptoms include infertility, loss of libido, menstrual irregularity and amenorrhea in women, and loss of libido and impotence in men.
