How does SCD affect blood pressure

How does SCD affect blood pressure?

Patients with SCD generally have lower blood pressure compared with their healthy unaffected counterparts due to presumed reduced vascular reactivity, compensatory systemic vasodilatation associated with microvascular disturbances from the sickling of red blood cells and thrombotic complications, elevated levels of prostaglandins and nitric oxide, and possibly kidney sodium and water wasting associated with suboptimal medullary concentrating activity.

Blood pressures in the “normal” range defined for the general population may thus represent hypertension in patients with SCD. Whether the lower blood pressure reduces long-term cardiovascular disease risks is not known as the median survival for patients with SCD is only 40 years.

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