How do the clinical manifestations of procainamide induced lupus differ from those of hydralazine induced lupus?
Patients with DILE caused by procainamide or hydralazine commonly have arthralgias/arthritis, myalgias, and fever but rarely manifest severe lupus nephritis or CNS involvement. Patients with procainamide-induced disease are more likely to have pleuritis and/or pericarditis, whereas patients with hydralazine-induced disease are more likely to have rashes.
