How common is systemic AL amyloidosis
Systemic AL amyloidosis occurs in 2% of individuals with monoclonal B-cell dyscrasias. Over 80% of cases are associated with “benign” monoclonal gammopathies with the remainder having multiple myeloma or, less often, Waldenstrom disease or non-Hodgkin lymphoma. Men and women are equally affected. The median age at diagnosis is 65 years, and 99% of patients are aged >40 years. Whites are more frequently affected than other races.
