Does histopathology predict prognosis of Focal segmental glomerulosclerosis?
Focal segmental glomerulosclerosis is diagnosed through findings on the kidney biopsy.
The glomerular scarring pattern has been classified as five variants of Focal segmental glomerulosclerosisbased solely on histologic description:
• Collapsing
• Tip
• Cellular
• Perihilar
• Focal segmental glomerulosclerosis not otherwise specified.
These variants are defined by the location and type of glomerular scars. Unfortunately, Focal segmental glomerulosclerosis variant assignment can be inconsistent between pathologists, and patient response to therapy is variable within groups of patients defined by Focal segmental glomerulosclerosis pathology variants.
Collapsing Focal segmental glomerulosclerosis appears to represent a particularly virulent form of Focal segmental glomerulosclerosis, and overall progression to ESKD is more rapid when compared with groups of Focal segmental glomerulosclerosis patients with other variants.
Increased tubular atrophy and interstitial scarring portend worse prognosis.
