Skip to content
Differential Diagnosis of recurrent fevers
What conditions need to be ruled out in patients with recurrent fevers?
1. Cyclic neutropenia. 2. Infectious disorders: • Hidden infectious focus (e.g., aortoenteric infection, Caroli’s disease). • Recurrent reinfection (host defense defect/primary immunodeficiency). • Specific infection (Borrelia or other relapsing fever, malaria, Whipple disease). 3. Noninfectious inflammatory disorders: • Systemic juvenile idiopathic arthritis, adult-onset Still’s disease. • Sarcoidosis. • Behçet’s disease. • Chronic recurrent multifocal osteomyelitis (CRMO, also called chronic noninfectious osteomyelitis [CNO]). • Inflammatory bowel disease (usually Crohn disease). • Sweet syndrome. • Schnitzler syndrome (IgM gammopathy, fever, urticarial rash, dermatographism, bone pain, splenomegaly, systemic symptoms; hematologic malignancy may be seen in 20% to 30%; reports of success with IL-1 inhibition). 4. Vascular/thromboembolic (recurrent pulmonary embolism or deep vein thrombosis). 5. Neoplastic: • Leukemia, lymphoma (including angioimmunoblastic T-cell lymphoma). • Solid tumor (neuroblastoma, pheochromocytoma, myxoma, colon, and renal cell carcinoma). • Paraneoplastic syndrome. 6. Hypothalamic disease.
Scroll to Top