Differences in clinical features of Reactive Arthritis and rheumatoid arthritis

Differences in clinical features of Reactive Arthritis and rheumatoid arthritis

A comparison of the clinical features of ReA with rheumatoid arthritis is elaborated in the below table

A Comparison of the Clinical Features of Reactive Arthritis with Rheumatoid Arthritis

FeatureReactive ArthritisRheumatoid Arthritis
Sex ratioMale > femaleFemale > male
Age20–40 yearsAll ages (most frequently: women aged 40–60 years, men older)
ArthritisOligoarticularPolyarticular
Large joints (asymmetric)MCP, PIP, wrist, MTP (symmetric)
EnthesitisYesNo
SpondylitisYesNo
Ocular diseaseConjunctivitis, uveitisKeratitis, scleromalacia, sicca, scleritis
Lung diseaseNoYes
UrethritisYesNo
Cutaneous lesionsKeratoderma, balanitisSubcutaneous nodules, vasculitis
Rheumatoid factor positiveNoYes (85%)
HLA associationHLA-B27 (80% of white males)HLA-DR4 (70%)

HLA , human leukocyte antigen; MCP , metacarpophalangeal; MTP , metatarsophalangeal; PIP , proximal interphalangeal.

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