Typical features of the synovial fluid in Rheumatoid Arthritis

What are the typical features of the synovial fluid in Rheumatoid Arthritis?

The synovial fluid is inflammatory, with white blood cell (WBC) counts typically between 5000 and 50,000/mm 3 . Rarely, synovial fluid WBC count can exceed 100,000/mm 3 (pseudoseptic) but infection must always be ruled out. Generally the differential shows a predominance (>50%) of PMNs. The protein level is elevated, and the glucose level may be lower than serum values (40%–60% of serum glucose). There are no crystals in the fluid, and cultures are negative. Unfortunately, there are no specific findings in the synovial fluid that allow a definitive diagnosis of RA.


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