Difference between primary and secondary pain syndromes

What is the difference between primary and secondary pain syndromes?

In primary pain syndromes, the pain itself is the disease. Examples include migraine, trigeminal neuralgia, and cluster headache. A secondary pain syndrome is due to an underlying (often structural) cause—for example, trigeminal neuralgia due to a tumor pressing on the cranial nerve. One of the major issues in any primary pain syndrome is to exclude an underlying destructive cause (tumor or infection).


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