Diagnostic yield of EUS-FNA in subepithelial lesions versus other diagnostic techniques
EUS-FNA has modest diagnostic yield in subepithelial lesions of approximately 60%. Endoscopic mucosal resection has high diagnostic yield (87%) with standard forcep bite-on-bite biopsies having the lowest yield (38%). Performing five FNA passes and having an on-site cytologist present may increase yield of EUS-FNA. It is unclear whether performing Trucut biopsy using larger cutting needles to obtain larger tissue samples increases diagnostic yield.