Diagnostic clues for hepatic amyloidosis
• Proteinuria—high association with co-occurring renal involvement.
• Howell–jolly bodies in the peripheral blood smear resulting from splenic infiltration causing hyposplenism.
• Hepatomegaly (>15 cm) out of proportion to liver function tests (one-third with hepatomegaly will have normal test results).
• Elevated alkaline phosphatase >1.5 times greater than upper limit of normal.
