Cushing Syndrome

4 Interesting Facts of Cushing Syndrome

  1. Condition of pathologic excess of glucocorticoids due to pituitary, adrenal, or other unusual tumors
  2. Cushing syndrome can cause fine excess hair along the face and chin, mimicking some features of hirsutism seen in women with nonclassic congenital adrenal hyperplasia
  3. However, Cushing syndrome is more likely when there are a large number of signs and symptoms with high discriminatory index (eg, proximal myopathy, facial plethora, violaceous striae, bruising)
  4. 24-hour urinary free cortisol, late-night salivary cortisol, or a 1-mg overnight dexamethasone suppression test are reasonable screening methods
    • Results suggestive of Cushing syndrome that require further investigation are: increased 24-hour urinary free cortisol, inappropriately elevated late-night salivary cortisol, and unsuppressed morning serum cortisol after dexamethasone
    • Testing and interpretation of these tests is usually complex; referral to endocrinologist is recommended

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