Complications of celiac sprue
- Collagenous sprue: Some cases of longstanding sprue, unresponsive to gluten-free diet, exhibit a thickened subepithelial collagen table greater than 10 μm along with marked villous blunting.
- Ulcerative jejunoileitis is characterized by multiple transverse ulcers in the small intestine, predominantly in the jejunum.
- Enteropathy-associated T-cell lymphoma is mostly seen in older adult patients with celiac disease.
- Carcinoma: Increased incidence of small bowel adenocarcinoma and carcinoma at other GIT sites has been reported. Also reported are carcinomas of oropharynx, lung, breast, and ovary.
