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Cognitive features of Progressive supranuclear palsy
What cognitive features are associated with Progressive supranuclear palsy?
Although the general view of Progressive supranuclear palsy as a disorder consisting of relatively l -DOPA-resistant parkinsonism, eye movement abnormalities, prominent axial rigidity, and prominent frontal dysfunction is useful, Progressive supranuclear palsy phenotypes can range from a pure akinesia/gait freezing variant, through classic Richardson’s syndrome with full-blown eye movement abnormalities, a behavioral variant Fronto Temporal Dementia or primary progressive aphasia, to a CB syndrome, depending upon the distribution of tau aggregates (going from brain stem to cortically predominant in the previous list).
Sources
- Murray ME, Kouri N, Lin WL, Jack CR, Dickson DW, Vemuri P: Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias. Alzheimers Res Ther 6(1):1-13, 2014.
- Gendron TF, Belzil VV, Zhang YJ, Petrucelli L: Mechanisms of toxicity in C9FTLD/ALS. Acta Neuropathol 127(3):359-376, 2014.
- Williams DR, Lees AJ: Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges. Lancet Neurol 8(3):270-279, 2009.
