What is chronic recurrent multifocal osteomyelitis (CRMO) and what causes it?
• Noninfectious lytic autoinflammatory bone disorder.
• No specific genetic mutation identified, but susceptibility locus identified on chromosome 18. Mutations in LPIN-2, located on chromosome 18, are associated with Majeed syndrome, a syndrome of CRMO and congenital dyserythropoietic anemia.
• Can be associated with inflammatory bowel disease and pyoderma gangrenosum ( Fig 79.2 ).
• Can be associated with pustular acne or palmoplantar pustulosis (SAPHO syndrome), or psoriatic lesions