Chronic recurrent multifocal osteomyelitis (CRMO)

What is chronic recurrent multifocal osteomyelitis (CRMO) and what causes it?

  • • Noninfectious lytic autoinflammatory bone disorder.
  • • No specific genetic mutation identified, but susceptibility locus identified on chromosome 18. Mutations in LPIN-2, located on chromosome 18, are associated with Majeed syndrome, a syndrome of CRMO and congenital dyserythropoietic anemia.
  • • Can be associated with inflammatory bowel disease and pyoderma gangrenosum ( Fig 79.2 ).
  • • Can be associated with pustular acne or palmoplantar pustulosis (SAPHO syndrome), or psoriatic lesions 
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