Central pontine myelinolysis (osmotic demyelination syndrome)

What is central pontine myelinolysis(osmotic demyelination syndrome)? 

Central pontine myelinolysis or osmotic demyelination syndrome, is another demyelinating disease that affects the brain stem white matter, mostly in the central pons and occasionally the cerebral hemispheres.

It occurs primarily in patients suffering from malnutrition or alcoholism complicated by hyponatremia.

Rapid correction of the hyponatremia has been implicated as a cause of the demyelination.

This disorder develops as a subacute progressive quadriparesis with lower cranial nerve involvement.

It is often fatal, but survival with recovered neurologic function is possible.

It can be prevented by correcting the electrolyte disturbance gradually rather than rapidly.


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