Cell type specific Dysfunction in Neurologic Disease

Cell type specific Dysfunction in Neurologic Disease

  1. Excitatory cortical neurons are preferentially lost in Alzheimer’s disease (AD).
  2. Inhibitory cortical neurons are preferentially affected in epilepsy.
  3. Neuromodulatory neurons are preferentially lost in AD (acetylcholine), Parkinson’s disease (PD) (dopamine), and narcolepsy (orexin/hypocretin).
  4. Astrocytes are preferentially affected in Alexander’s disease and neuromyelitis optica.
  5. Oligodendroglia and Schwann cells are preferentially affected in multiple sclerosis and Charcot–Marie–Tooth disease, respectively.

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