Cell type specific Dysfunction in Neurologic Disease
- Excitatory cortical neurons are preferentially lost in Alzheimer’s disease (AD).
- Inhibitory cortical neurons are preferentially affected in epilepsy.
- Neuromodulatory neurons are preferentially lost in AD (acetylcholine), Parkinson’s disease (PD) (dopamine), and narcolepsy (orexin/hypocretin).
- Astrocytes are preferentially affected in Alexander’s disease and neuromyelitis optica.
- Oligodendroglia and Schwann cells are preferentially affected in multiple sclerosis and Charcot–Marie–Tooth disease, respectively.