Causes of secretory watery diarrhea

Likely causes of secretory watery diarrhea

  • • Bacterial toxins
  • • Ileal bile acid malabsorption
  • • Inflammatory bowel disease (ulcerative colitis, Crohn’s disease, microscopic colitis [lymphocytic and collagenous colitis], diverticulitis)
  • • Vasculitis
  • • Drugs and poisons
  • • Stimulant laxative abuse
  • • Disordered motility or regulation (postvagotomy diarrhea, postsympathectomy diarrhea, diabetic autonomic neuropathy, amyloidosis, irritable bowel syndrome)
  • • Endocrine diarrhea (hyperthyroidism, Addison’s disease, gastrinoma, vasoactive intestinal polypeptide tumor [VIPoma], somatostatinoma, carcinoid syndrome, medullary carcinoma of the thyroid, mastocytosis)
  • • Other tumors (colon cancer, lymphoma, villous adenoma)
  • • Idiopathic secretory diarrhea (epidemic secretory [Brainerd’s] diarrhea, sporadic idiopathic secretory diarrhea)
  • • Congenital syndromes (e.g., congenital chloridorrhea)
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