Causes of Minimal change disease
Minimal change disease is an immune-mediated disease, thought to be due to a circulating factor capable of inducing proteinuria.
Presumably the circulating factor is secreted by lymphoid cells and functions as a vascular permeability factor and directly affects podocyte function.
Although most cases are idiopathic, Minimal change disease, particularly in adults, may be associated with neoplastic disease such as lymphoma, toxic or allergic reactions to drugs, certain infections, allergies, or other autoimmune disorders.
