Can a positive ANA occur in a normal healthy individual

Can a positive ANA occur in a normal healthy individual?

Yes. The frequency depends on ANA titer and patient characteristics:

• ANA 1:40: 20%–30% of healthy individuals can be positive

• ANA 1:80: 10%–15% positive

• ANA 1:160: 5% positive

• ANA 1:320: 3% positive

• Healthy relative of an SLE patient: 5%–25% positive (usually low titers)

• Elderly (age >70 years): up to 70% positive at ANA titer 1:40

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