Autoimmune Diseases Associated with Anticytoplasmic Antibodies

Autoimmune Diseases Associated with Anticytoplasmic Antibodies

DiseaseCytoplasmic AntigenFrequency
PolymyositistRNA synthetase (anti-Jo-1, others)20%–30%
Signal recognition particle4%
Systemic lupus erythematosusRibosomal P5%–10%
Granulomatosis with polyangiitisSerine proteinase-3 (seen only in neutrophils)90%
Microscopic polyangiitis (+ other anti-neutrophil cytoplasmic antibody vasculitides)Myeloperoxidase, others (seen only in neutrophils)70%
Primary biliary cirrhosisMitochondria80%

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