Are antineutrophil cytoplasmic antibodies ever seen in systemic Drug induced Lupus Erythematosus

Sharing is caring!

Are antineutrophil cytoplasmic antibodies ever seen in systemic Drug induced Lupus Erythematosus?

Up to 80% to 85% of patients with minocycline-induced lupus can have a positive perinuclear ANCA (pANCA) with or without specificity for myeloperoxidase (anti-MPO). PTU and hydralazine can both cause DILE with an associated pANCA. However, both PTU and hydralazine therapy can also cause a positive pANCA usually with anti-MPO specificity that is associated with a more severe pauci-immune vasculitis with a necrotizing glomerulonephritis and possible pulmonary involvement (see Chapter 29 : Antineutrophil Cytoplasmic Antibody-Associated Vasculitis). Notably, 15% to 20% of idiopathic SLE patients can have a positive ANCA.

Sharing is caring!

You cannot copy content of this page

15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top