Are antineutrophil cytoplasmic antibodies ever seen in systemic Drug induced Lupus Erythematosus?
Up to 80% to 85% of patients with minocycline-induced lupus can have a positive perinuclear ANCA (pANCA) with or without specificity for myeloperoxidase (anti-MPO). PTU and hydralazine can both cause DILE with an associated pANCA. However, both PTU and hydralazine therapy can also cause a positive pANCA usually with anti-MPO specificity that is associated with a more severe pauci-immune vasculitis with a necrotizing glomerulonephritis and possible pulmonary involvement (see Chapter 29 : Antineutrophil Cytoplasmic Antibody-Associated Vasculitis). Notably, 15% to 20% of idiopathic SLE patients can have a positive ANCA.
