What are the acquired causes of hyperuricemia?
Urate overproduction: excess dietary purine consumption, accelerated hepatic ATP degradation in alcohol abuse or fructose ingestion, and increased nucleotide turnover in myeloproliferative and lymphoproliferative disorders.
Urate underexcretion: renal disease, lead nephropathy (saturnine gout), inhibition of tubular urate secretion (keto- and lactic acidosis), select drugs (see Question 9), and miscellaneous causes such as hyperparathyroidism, hypothyroidism, and respiratory acidosis.