Why do the elderly tend to have more complications with NSAIDs

Why do the elderly tend to have more complications with NSAIDs?

The elderly have more complications from these drugs than any other group of patients because of:

  • • Altered drug absorption. The gastric pH rises with age. Active absorption and transport of drugs may be altered.
  • • Reduced drug distribution.
  • • Decreased protein-binding. Plasma albumin decreases with aging, decreasing protein-binding sites.
  • • Hepatic metabolism and renal excretion may be altered.
  • • Polypharmacy. Some patient’s medications may have drug interactions with NSAIDs.
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