Use of renin inhibitors in Hypertension

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Use of renin inhibitors in Hypertension

Initial enthusiasm for these drugs has been tempered by the findings of the ALTITUDE trial, which randomized patients with type 2 diabetes mellitus to:

  • • Aliskiren and an ACEi inhibitor or ARB; or
  • • Placebo and an ACEi inhibitor or ARB

ALTITUDE was stopped early, after there was a signal for increased stroke in the aliskiren group, as well as a trend to increased renal and cardiovascular events with aliskiren.

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