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What is Upadacitinib
Upadacitinib is an oral Janus kinase (JAK) inhibitor and is considered a targeted synthetic disease-modifying antirheumatic drug (tsDMARD).
Brand Name
RINVOQ
Indications
- rheumatoid arthritis
Side Effects
- abdominal pain
- anemia
- candidiasis
- cough
- elevated hepatic enzymes
- fever
- GI perforation
- hepatotoxicity
- hypercholesterolemia
- hyperlipidemia
- hypertriglyceridemia
- infection
- laryngitis
- lymphoma
- lymphopenia
- nausea
- neutropenia
- new primary malignancy
- pharyngitis
- pulmonary embolism
- rhinitis
- sinusitis
- skin cancer
- thromboembolism
- thrombosis
Monitoring Parameters
- CBC with differential
- hemoglobin/hematocrit
- LFTs
- serum cholesterol profile
- skin cancer screening exam
- tuberculin skin test
Contraindications
- acquired immunodeficiency syndrome (AIDS)
- anemia
- breast-feeding
- children
- contraception requirements
- corticosteroid therapy
- diverticulitis
- fungal infection
- geriatric
- GI perforation
- hepatic disease
- hepatitis
- hepatitis B exacerbation
- herpes infection
- human immunodeficiency virus (HIV) infection
- hypercholesterolemia
- hyperlipidemia
- immunosuppression
- infants
- infection
- lymphoma
- neutropenia
- new primary malignancy
- pregnancy
- pregnancy testing
- pulmonary disease
- reproductive risk
- skin cancer
- thromboembolic disease
- thromboembolism
- thrombosis
- tuberculosis
- vaccination
- viral infection
Interactions
- Abatacept
- Adalimumab
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anakinra
- Antithymocyte Globulin
- Apalutamide
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azathioprine
- Baricitinib
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Brodalumab
- Canakinumab
- Carbamazepine
- Ceritinib
- Certolizumab pegol
- Chloramphenicol
- Clarithromycin
- Cobicistat
- Conivaptan
- Cyclosporine
- Daclizumab
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Etanercept
- Everolimus
- Fosamprenavir
- Fosphenytoin
- Golimumab
- grapefruit juice
- Guselkumab
- Idelalisib
- Indinavir
- Infliximab
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ixekizumab
- Ketoconazole
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Mercaptopurine, 6-MP
- Mifepristone
- Mitotane
- Nefazodone
- Nelfinavir
- Ombitasvir; Paritaprevir; Ritonavir
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Ribociclib
- Ribociclib; Letrozole
- Rifampin
- Ritonavir
- Rituximab
- Rituximab; Hyaluronidase
- Ruxolitinib
- Saquinavir
- Sarilumab
- Secukinumab
- Sirolimus
- St. John’s Wort, Hypericum perforatum
- Tacrolimus
- Telithromycin
- Tipranavir
- Tocilizumab
- Tofacitinib
- Tucatinib
- Tumor Necrosis Factor modifiers
- Ustekinumab
- Voriconazole
