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What is Trabectedin
Trabectedin is an alkylating agent indicated for the treatment of unresectable or metastatic liposarcoma and leiomyosarcoma in patients that had previously received anthracycline-containing chemotherapy.
Neutropenic sepsis, hepatotoxicity, rhabdomyolysis, and cardiomyopathy have been reported with trabectedin use.
Brand Name
Yondelis
Indications
- soft-tissue sarcoma
Side Effects
- anemia
- anemia
- anorexia
- anorexia
- arthralgia
- asthenia
- capillary leak syndrome
- cardiomyopathy
- cardiomyopathy
- constipation
- constipation
- diarrhea
- diarrhea
- dyspnea
- dyspnea
- elevated hepatic enzymes
- elevated hepatic enzymes
- fatigue
- fatigue
- headache
- headache
- heart failure
- hepatic failure
- hyperbilirubinemia
- hyperbilirubinemia
- hypoalbuminemia
- hypoalbuminemia
- hypoesthesia
- insomnia
- insomnia
- malaise
- myalgia
- nausea
- nausea
- neutropenia
- neutropenia
- paresthesias
- peripheral edema
- peripheral edema
- peripheral neuropathy
- pulmonary embolism
- renal failure (unspecified)
- rhabdomyolysis
- thrombocytopenia
- thrombocytopenia
- vomiting
- vomiting
Monitoring Parameters
- CBC with differential
- creatine phosphokinase (CPK)
- ejection fraction
- LFTs
- pregnancy testing
Contraindications
- bone marrow suppression
- breast-feeding
- capillary leak syndrome
- cardiac disease
- cardiomyopathy
- chemotherapy
- contraception requirements
- extravasation
- fungal infection
- geriatric
- heart failure
- hepatic disease
- hepatotoxicity
- herpes infection
- infection
- infertility
- male-mediated teratogenicity
- neutropenia
- pregnancy
- pregnancy testing
- radiation therapy
- reproductive risk
- rhabdomyolysis
- ventricular dysfunction
- viral infection
Interactions
- Aldesleukin, IL-2
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Boceprevir
- Bosentan
- Carbamazepine
- Ceritinib
- Chloramphenicol
- Clarithromycin
- Cobicistat
- Conivaptan
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Flutamide
- Fosamprenavir
- Fosphenytoin
- grapefruit juice
- Idelalisib
- Indinavir
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Letermovir
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Mifepristone
- Mitotane
- Nefazodone
- Nelfinavir
- Ombitasvir; Paritaprevir; Ritonavir
- Palifermin
- Penicillamine
- Pentobarbital
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Ribociclib
- Ribociclib; Letrozole
- Rifampin
- Ritonavir
- Saquinavir
- St. John’s Wort, Hypericum perforatum
- Telaprevir
- Telithromycin
- Tipranavir
- Tuberculin Purified Protein Derivative, PPD
- Tucatinib
- Voriconazole
