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What is Tiludronate
NOTE: This drug is discontinued in the U.S.
Tiludronate was a bisphosphonate used in the treatment of Paget’s disease.
Guidelines for Paget’s disease preferentially recommend other potent bisphosphonates for this indication.
Tiludronate was never approved in the U.S. for osteoporosis treatment or prevention as studies failed to produce convincing evidence of efficacy for reducing fracture risk in these patients versus placebo.
Tiludronate was approved by the FDA in 1997, but was discontinued from marketing in the U.S. in 2011.
Brand Name
Skelid
Indications
- Paget’s disease
For the treatment of Paget’s disease
Side Effects
- abdominal pain
- anorexia
- anxiety
- arthralgia
- asthenia
- atrial fibrillation
- back pain
- bone fractures
- bone pain
- cataracts
- chest pain (unspecified)
- conjunctivitis
- constipation
- cough
- diarrhea
- dizziness
- dyspepsia
- dysphagia
- edema
- esophageal ulceration
- esophagitis
- fatigue
- flatulence
- flushing
- gastritis
- headache
- hyperhidrosis
- hypertension
- infection
- insomnia
- myalgia
- nausea
- ocular inflammation
- ocular pain
- odynophagia
- osteonecrosis
- paresthesias
- peptic ulcer
- peripheral edema
- pharyngitis
- pruritus
- pyrosis (heartburn)
- rash
- rhinitis
- sinusitis
- Stevens-Johnson syndrome
- syncope
- uveitis
- vertigo
- visual impairment
- vomiting
- xerostomia
Monitoring Parameters
- serum 25(OH)hydroxyvitamin D concentrations
- serum alkaline phosphatase
- serum calcium
- serum creatinine/BUN
- serum phosphate
Contraindications
- achalasia
- anemia
- breast-feeding
- chemotherapy
- children
- coagulopathy
- corticosteroid therapy
- dental disease
- dental work
- dysphagia
- esophageal stricture
- esophagitis
- gastritis
- gastroesophageal reflux disease (GERD)
- geriatric
- GI disease
- hiatal hernia
- hyperparathyroidism
- hypocalcemia
- inability to stand or sit upright
- infection
- phosphonate hypersensitivity
- pregnancy
- renal failure
- renal impairment
- vitamin D deficiency
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amlodipine; Celecoxib
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Calcium
- Calcium Acetate
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Calcium Chloride
- Calcium Gluconate
- Calcium; Vitamin D
- Celecoxib
- Chromium
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Esomeprazole; Naproxen
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Etodolac
- Famotidine; Ibuprofen
- Fenoprofen
- Flurbiprofen
- food
- Hetastarch; Dextrose; Electrolytes
- Hydrocodone; Ibuprofen
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Iron
- Iron Salts
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lanthanum Carbonate
- Magnesium
- Magnesium Citrate
- Magnesium Salts
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nonsteroidal antiinflammatory drugs
- Omeprazole; Sodium Bicarbonate
- Oxaprozin
- Piroxicam
- Polycarbophil
- Polysaccharide-Iron Complex
- Rofecoxib
- Sodium Bicarbonate
- Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
- Sulindac
- Tolmetin
- Valdecoxib
