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What is Ticarcillin and Clavulanic Acid medicine combination
Timentin(R) is a combination of ticarcillin and clavulanic acid.
Ticarcillin is a parenteral, semisynthetic, extended-spectrum penicillin.
Clavulanic acid is a beta-lactamase inhibitor that alone has weak antibacterial activity but in combination with ticarcillin extends the spectrum of the drug to include many beta-lactamase-producing organisms.
Clinically, ticarcillin-clavulanic acid is used to treat infections requiring treatment with multiple antibiotics or to treat bacteria that are resistant to other gram-negative antibiotics.
Ticarcillin clavulanic acid frequently is used for intra-abdominal infections and respiratory infections.
Ticarcillin clavulanic acid was FDA-approved in April 1985.
Brand Name
Timentin
Indications
- Acinetobacter baumannii
- Acinetobacter calcoaceticus
- Acinetobacter haemolyticus
- Acinetobacter lwoffii
- Actinomyces sp.
- Bacillus anthracis
- bacteremia
- Bacteroides fragilis
- Bacteroides sp.
- Bifidobacterium sp.
- bone and joint infections
- Citrobacter sp.
- Clostridium bifermentans
- Clostridium difficile
- Clostridium perfringens
- Clostridium ramosum
- Clostridium sp.
- Clostridium sporogenes
- Corynebacterium sp.
- cystic fibrosis
- Eikenella corrodens
- endometritis
- Enterobacter cloacae
- Enterobacter sp.
- Escherichia coli
- Eubacterium sp.
- febrile neutropenia
- Fusobacterium necrophorum
- Fusobacterium nucleatum
- Fusobacterium sp.
- gynecologic infections
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Haemophilus parainfluenzae
- intraabdominal infections
- Klebsiella oxytoca
- Klebsiella pneumoniae
- Klebsiella sp.
- Lactobacillus sp.
- lower respiratory tract infections
- Moraxella catarrhalis
- Morganella morganii
- Neisseria gonorrhoeae
- Neisseria meningitidis
- Pasteurella multocida
- Peptococcus sp.
- Peptostreptococcus sp.
- pericarditis
- peritonitis
- pneumonia
- Prevotella melaninogenica
- Propionibacterium sp.
- Proteus mirabilis
- Proteus penneri
- Proteus vulgaris
- Providencia rettgeri
- Providencia stuartii
- Pseudomonas aeruginosa
- Pseudomonas sp.
- Salmonella sp.
- sepsis
- Serratia marcescens
- Shigella sp.
- skin and skin structure infections
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- Staphylococcus saprophyticus
- Stenotrophomonas maltophilia
- Streptococcus agalactiae (group B streptococci)
- Streptococcus bovis
- Streptococcus dysgalactiae
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- urinary tract infection (UTI)
- Veillonella sp.
- Viridans streptococci
Side Effects
- abdominal pain
- anaphylactic shock
- anaphylactoid reactions
- anemia
- angioedema
- arthralgia
- bleeding
- chills
- cholestasis
- diarrhea
- dysgeusia
- elevated hepatic enzymes
- erythema multiforme
- fever
- flatulence
- headache
- hemolysis
- hemorrhagic cystitis
- hepatitis
- hyperbilirubinemia
- hypernatremia
- hypokalemia
- injection site reaction
- jaundice
- leukopenia
- malaise
- myalgia
- nausea
- neutropenia
- phlebitis
- platelet dysfunction
- prolonged bleeding time
- pruritus
- pseudomembranous colitis
- rash
- seizures
- serum sickness
- Stevens-Johnson syndrome
- stomatitis
- superinfection
- thrombocytopenia
- thrombosis
- toxic epidermal necrolysis
- urticaria
- vomiting
Monitoring Parameters
- LFTs
- serum creatinine/BUN
- serum potassium
- serum sodium
Contraindications
- asthma
- breast-feeding
- carbapenem hypersensitivity
- cephalosporin hypersensitivity
- coagulopathy
- colitis
- cystic fibrosis
- diabetes mellitus
- diarrhea
- eczema
- electrolyte imbalance
- geriatric
- GI disease
- heart failure
- hemophilia
- hypokalemia
- inflammatory bowel disease
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal disease
- renal failure
- renal impairment
- sodium restriction
- ulcerative colitis
- viral infection
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Anticoagulants
- Antithrombin III
- Apixaban
- Argatroban
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Betrixaban
- Bivalirudin
- Choline Salicylate; Magnesium Salicylate
- Colchicine; Probenecid
- Dabigatran
- Dalteparin
- Danaparoid
- Desirudin
- Dienogest; Estradiol valerate
- Digoxin
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Edoxaban
- Elagolix; Estradiol; Norethindrone acetate
- Enoxaparin
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethacrynic Acid
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Fondaparinux
- Furosemide
- Heparin
- Indomethacin
- Lepirudin
- Leuprolide; Norethindrone
- Levonorgestrel
- Magnesium Salicylate
- Mestranol; Norethindrone
- Methotrexate
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Pentosan
- Probenecid
- Rivaroxaban
- Salsalate
- Segesterone Acetate; Ethinyl Estradiol
- Sodium Benzoate; Sodium Phenylacetate
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Tetracyclines
- Tinzaparin
- Typhoid Vaccine
- Warfarin
