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What is Tacrine
Tacrine hydrochloride is a cholinesterase (ChE) inhibitor.
It was the first drug approved for improving cognitive symptoms (i.e., memory, attention, reason, language, and the ability to perform simple tasks) associated with Alzheimer’s disease.
A recent meta-analysis of 12 trials involving 1984 patients treated with tacrine for up to 1 year showed that tacrine reduces deterioration in cognitive performance in the first 3 months of therapy as measured by the Mini-Mental State Examination (MMSE) and Clinical Global Impression of Change (CGIC) scales.
Brand Name
Cognex
Indications
- Alzheimer’s disease
For the treatment of symptoms of mild to moderate Alzheimer’s disease
Side Effects
- agitation
- anorexia
- anxiety
- ataxia
- AV block
- blurred vision
- bradycardia
- constipation
- diarrhea
- dizziness
- dyspepsia
- dysuria
- elevated hepatic enzymes
- flatulence
- hallucinations
- hepatic failure
- hepatitis
- hyperkinesis
- hypertension
- hypotension
- insomnia
- jaundice
- myalgia
- nausea
- palpitations
- seizures
- syncope
- tremor
- urinary retention
- visual impairment
- vomiting
- wheezing
- xerostomia
Monitoring Parameters
- LFTs
- neurologic function
- weight
Contraindications
- abrupt discontinuation
- anticholinergic medications
- asthma
- AV block
- bladder obstruction
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- children
- chronic obstructive pulmonary disease (COPD)
- diarrhea
- geriatric
- GI bleeding
- GI disease
- GI obstruction
- head trauma
- hepatic disease
- hypotension
- ileus
- increased intracranial pressure
- jaundice
- Parkinson’s disease
- peptic ulcer disease
- pregnancy
- QT prolongation
- seizure disorder
- seizures
- sick sinus syndrome
- surgery
- syncope
- tobacco smoking
- urinary tract obstruction
Interactions
- Acebutolol
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Diphenhydramine
- Acrivastine; Pseudoephedrine
- Albendazole
- Aldesleukin, IL-2
- Amantadine
- Ambenonium Chloride
- Amifampridine
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amoxapine
- Anagrelide
- Anticholinergics
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA; Caffeine; Orphenadrine
- Atenolol
- Atenolol; Chlorthalidone
- Bendamustine
- Bendroflumethiazide; Nadolol
- Beta-blockers
- Betaxolol
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Brimonidine; Timolol
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Caffeine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pyrilamine
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Carteolol
- Carvedilol
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroprocaine
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Cholinergic agonists
- Cimetidine
- Ciprofloxacin
- Clemastine
- Clozapine
- Cocaine
- Cyclizine
- Cyclobenzaprine
- Cyproheptadine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Diazepam
- Digoxin
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Disopyramide
- Dorzolamide; Timolol
- Doxercalciferol
- Doxylamine
- Doxylamine; Pyridoxine
- Duloxetine
- Eltrombopag
- Esmolol
- Estradiol; Levonorgestrel
- Estrogens
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Etomidate
- Fluoxetine; Olanzapine
- Fluvoxamine
- food
- Fospropofol
- Green Tea
- Halogenated Anesthetics
- Haloperidol
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydroxyzine
- Ketamine
- Labetalol
- Leflunomide
- Levobetaxolol
- Levobunolol
- Levobupivacaine
- Levonorgestrel
- Lidocaine
- Lidocaine; Prilocaine
- Maprotiline
- Meclizine
- Melatonin
- Mepivacaine
- Mepivacaine; Levonordefrin
- Methocarbamol
- Methohexital
- Methotrexate
- Metoclopramide
- Metoprolol
- Mexiletine
- Nadolol
- Nebivolol
- Nebivolol; Valsartan
- Nonsteroidal antiinflammatory drugs
- Olanzapine
- Orphenadrine
- Penbutolol
- Pimozide
- Pindolol
- Polymyxins
- Prilocaine
- Prilocaine; Epinephrine
- Procaine
- Propafenone
- Propofol
- Propranolol
- Ramelteon
- Rasagiline
- Riluzole
- Ropinirole
- Ropivacaine
- Sedating H1-blockers
- Solifenacin
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Terbinafine
- Tetracaine
- Theophylline, Aminophylline
- Thiabendazole
- Thiopental
- Thioridazine
- Timolol
- Tizanidine
- tobacco
- Tolterodine
- Tricyclic antidepressants
- Triprolidine
- Trospium
- Vemurafenib
- Warfarin
- Zileuton
