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What is Sunitinib
Sunitinib is an oral, multitargeted tyrosine kinase inhibitor with anti-angiogenic and anti-tumor activities due to selective inhibition of several receptor tyrosine kinases.
Activation of gene pathways by hypoxia, such as vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF), are common in solid tumors. These genes are implicated in tumor angiogenesis and proliferation.
It is indicated for the treatment of progressive GI stromal tumor (GIST), adjuvant renal cell carcinoma (RCC) following nephrectomy in patients at high risk of recurrence, advanced RCC, and progressive pancreatic neuroendocrine tumor (pNET).
Brand Name
Sutent
Indications & Dosage
- gastrointestinal stromal tumors (GIST)
- malignant neuroendocrine tumor (NET)
- renal cell cancer
For the treatment of renal cell cancer (RCC)
for the adjuvant treatment of renal cell cancer (RCC) in patients at high risk of recurrence following nephrectomy
Side Effects
- abdominal pain
- abdominal pain
- alopecia
- anemia
- anemia
- angioedema
- anorexia
- anorexia
- arthralgia
- arthralgia
- asthenia
- asthenia
- back pain
- back pain
- bleeding
- bleeding
- cardiomyopathy
- chest pain (unspecified)
- chest pain (unspecified)
- chills
- chills
- cholecystitis
- constipation
- constipation
- cough
- cough
- depression
- diarrhea
- diarrhea
- dizziness
- dizziness
- dysgeusia
- dysgeusia
- dyspepsia
- dyspepsia
- dyspnea
- dyspnea
- edema
- edema
- elevated hepatic enzymes
- elevated hepatic enzymes
- epistaxis
- epistaxis
- erythema
- erythema
- erythema multiforme
- esophagitis
- esophagitis
- exfoliative dermatitis
- fatigue
- fatigue
- fever
- fever
- flatulence
- gastroesophageal reflux
- gastroesophageal reflux
- GI bleeding
- GI perforation
- gingivitis
- glossitis
- hair discoloration
- hair discoloration
- headache
- headache
- heart failure
- hematemesis
- hematoma
- hematuria
- hemolytic-uremic syndrome
- hemoptysis
- hemorrhoids
- hepatic failure
- hepatotoxicity
- hyperamylasemia
- hyperamylasemia
- hyperbilirubinemia
- hyperbilirubinemia
- hypercalcemia
- hypercalcemia
- hyperglycemia
- hyperglycemia
- hyperkalemia
- hyperkalemia
- hypernatremia
- hypertension
- hypertension
- hypertensive crisis
- hyperthyroidism
- hyperuricemia
- hyperuricemia
- hypoalbuminemia
- hypoalbuminemia
- hypocalcemia
- hypocalcemia
- hypoglycemia
- hypoglycemia
- hypokalemia
- hypokalemia
- hypomagnesemia
- hyponatremia
- hyponatremia
- hypophosphatemia
- hypophosphatemia
- hypothyroidism
- hypothyroidism
- impaired wound healing
- infection
- influenza
- insomnia
- insomnia
- insomnia
- leukoencephalopathy
- leukopenia
- leukopenia
- lymphopenia
- lymphopenia
- maculopapular rash
- melena
- myalgia
- myalgia
- myocardial infarction
- myopathy
- nausea
- nausea
- necrotizing fasciitis
- nephrotic syndrome
- neutropenia
- neutropenia
- oral ulceration
- osteonecrosis
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- pancreatitis
- peripheral edema
- peripheral edema
- pharyngitis
- pleural effusion
- proteinuria
- pruritus
- pruritus
- psoriaform rash
- pulmonary embolism
- QT prolongation
- rash
- rash
- renal failure (unspecified)
- rhabdomyolysis
- seizures
- skin discoloration
- skin discoloration
- Stevens-Johnson syndrome
- stomatitis
- stomatitis
- stroke
- thrombocytopenia
- thrombocytopenia
- thromboembolism
- thrombosis
- thrombotic microangiopathy
- thrombotic thrombocytopenic purpura (TTP)
- torsade de pointes
- toxic epidermal necrolysis
- tumor lysis syndrome (TLS)
- vomiting
- vomiting
- weight loss
- weight loss
- xerosis
- xerosis
- xerostomia
Monitoring Parameters
- blood glucose
- CBC with differential
- ECG
- ejection fraction
- LFTs
- pregnancy testing
- serum electrolytes
- urinalysis
Contraindications
- alcoholism
- angina
- bleeding
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- cardiomyopathy
- children
- contraception requirements
- coronary artery bypass graft surgery (CABG)
- coronary artery disease
- dental disease
- dental work
- diabetes mellitus
- females
- geriatric
- heart failure
- hepatic disease
- hypertension
- hyperthyroidism
- hypocalcemia
- hypoglycemia
- hypokalemia
- hypomagnesemia
- hypothyroidism
- infertility
- long QT syndrome
- malnutrition
- myocardial infarction
- pregnancy
- pregnancy testing
- proteinuria
- QT prolongation
- radiation therapy
- renal failure
- reproductive risk
- stroke
- surgery
- thyroid disease
- tumor lysis syndrome (TLS)
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Aclidinium; Formoterol
- Albuterol
- Albuterol; Ipratropium
- Alfuzosin
- Amiodarone
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Apalutamide
- Apomorphine
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Atomoxetine
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azithromycin
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bexarotene
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bosentan
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Butabarbital
- Carbamazepine
- Cenobamate
- Ceritinib
- Chloramphenicol
- Chloroquine
- Chlorpromazine
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clofazimine
- Clozapine
- Cobicistat
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Conivaptan
- Crizotinib
- Dabrafenib
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Degarelix
- Delavirdine
- Desflurane
- Deutetrabenazine
- Dexamethasone
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Dronedarone
- Droperidol
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Encorafenib
- Enflurane
- Entrectinib
- Enzalutamide
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Eslicarbazepine
- Etravirine
- Ezogabine
- Fingolimod
- Flecainide
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Formoterol
- Formoterol; Mometasone
- Fosamprenavir
- Foscarnet
- Fosphenytoin
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- grapefruit juice
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Histrelin
- Hydroxychloroquine
- Hydroxyzine
- Ibutilide
- Idelalisib
- Iloperidone
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indinavir
- Inotuzumab Ozogamicin
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ivosidenib
- Ketoconazole
- Lapatinib
- Lefamulin
- Lenvatinib
- Letermovir
- Leuprolide
- Leuprolide; Norethindrone
- Levalbuterol
- Levofloxacin
- Lithium
- Lofexidine
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorlatinib
- Lumacaftor; Ivacaftor
- Macimorelin
- Maprotiline
- Mefloquine
- Meperidine; Promethazine
- Mephobarbital
- Metaproterenol
- Methadone
- Methohexital
- Metronidazole
- Midostaurin
- Mifepristone
- Mirtazapine
- Mitotane
- Modafinil
- Moxifloxacin
- Nafcillin
- Nefazodone
- Nelfinavir
- Nevirapine
- Nilotinib
- Norfloxacin
- Octreotide
- Ofloxacin
- Olanzapine
- Olodaterol
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Ondansetron
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxcarbazepine
- Ozanimod
- Paliperidone
- Panobinostat
- Pasireotide
- Pazopanib
- Pentamidine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phenylephrine; Promethazine
- Phenytoin
- Pimavanserin
- Pimozide
- Pirbuterol
- Pitolisant
- Posaconazole
- Primaquine
- Primidone
- Procainamide
- Prochlorperazine
- Promethazine
- Propafenone
- Quetiapine
- Quinidine
- Quinine
- Ranolazine
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rilpivirine
- Risperidone
- Ritonavir
- Romidepsin
- Salmeterol
- Saquinavir
- Selpercatinib
- Sertraline
- Sevoflurane
- Short-acting beta-agonists
- Siponimod
- Solifenacin
- Sorafenib
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Tacrolimus
- Tamoxifen
- Telavancin
- Telithromycin
- Temsirolimus
- Terbutaline
- Tetrabenazine
- Thioridazine
- Tiotropium; Olodaterol
- Tipranavir
- Tolterodine
- Toremifene
- Trazodone
- Tricyclic antidepressants
- Trifluoperazine
- Triptorelin
- Tucatinib
- Umeclidinium; Vilanterol
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Voriconazole
- Vorinostat
- Ziprasidone
