St Johns Wort (Hypericum perforatum) goat weed, klamath weed

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What is St Johns Wort (Hypericum perforatum)

St. John’s wort, Hypericum perforatum, is an aromatic perennial native to Europe, parts of Africa and Asia, and the western US. Its yellow flowers are especially bright on June 24, the traditional birthday of St. John the Baptist, hence the name “St. John’s wort”.

Other names include “goat weed” or “klamath weed”. The leaves and flowering tops of Hypericum perforatum yield about 0.1% hypericin, pseudohypericin, and related naphthodianthrones. Flavonoids such as amentoflavone, luteolin, kaempferol, and quercetin and the glycosides hyperoside and rutinoside have also been identified in the plant.

St. John’s wort is widely used in Europe for treatment of depression, dysthymia, and sleep disturbances. The German Commission E has recognized St. John’s wort as a “modestly effective” antidepressant.

Indications

  • burns
  • depression

Side Effects

  1. abdominal pain
  2. anxiety
  3. cataracts
  4. dizziness
  5. drowsiness
  6. dysesthesia
  7. dyspepsia
  8. ejaculation dysfunction
  9. headache
  10. increased urinary frequency
  11. infertility
  12. insomnia
  13. mania
  14. orgasm dysfunction
  15. peripheral neuropathy
  16. photosensitivity
  17. restlessness
  18. serotonin syndrome
  19. urticaria
  20. withdrawal
  21. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acquired immunodeficiency syndrome (AIDS)
  • anticoagulant therapy
  • breast-feeding
  • cardiac disease
  • cerebrovascular disease
  • children
  • depression
  • hepatic disease
  • human immunodeficiency virus (HIV) infection
  • hypertension
  • infertility
  • mania
  • MAOI therapy
  • neonates
  • neurological disease
  • organ transplant
  • pregnancy
  • psychosis
  • renal disease
  • renal impairment
  • suicidal ideation
  • sunlight (UV) exposure
  • surgery
  • thyroid disease

Interactions

  • Abacavir; Dolutegravir; Lamivudine
  • Abemaciclib
  • Abiraterone
  • Acalabrutinib
  • Acetaminophen
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Acitretin
  • Acrivastine; Pseudoephedrine
  • Afatinib
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  • Alosetron
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  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
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  • Amoxapine
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
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  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
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  • Avapritinib
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  • Bedaquiline
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  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzphetamine
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  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Budesonide
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  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cariprazine
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  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Cilostazol
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  • Dasatinib
  • Deflazacort
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  • Desvenlafaxine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexlansoprazole
  • Dexmethylphenidate
  • Dextromethorphan
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin
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  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
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  • Diazepam
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  • Diethylpropion
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  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
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  • Diphenhydramine; Phenylephrine
  • Disopyramide
  • Dobutamine
  • Docetaxel
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  • Donepezil
  • Donepezil; Memantine
  • Dopamine
  • Doravirine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Doxepin
  • Doxercalciferol
  • Doxorubicin
  • Dronabinol
  • Dronedarone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Duloxetine
  • Duvelisib
  • Edoxaban
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
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  • Elagolix
  • Elagolix; Estradiol; Norethindrone acetate
  • Elbasvir; Grazoprevir
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  • Enalapril; Felodipine
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  • Epinephrine
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  • Estrogens
  • Estropipate
  • Eszopiclone
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
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  • Etomidate
  • Etravirine
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  • Exemestane
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  • Fedratinib
  • Felodipine
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  • Flibanserin
  • Fluoxetine; Olanzapine
  • Flurazepam
  • food
  • Fosamprenavir
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  • Green Tea
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guaifenesin; Pseudoephedrine
  • Guanfacine
  • Halobetasol; Tazarotene
  • Haloperidol
  • Halothane
  • Homatropine; Hydrocodone
  • Hydantoins
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
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  • Hydrocodone; Pseudoephedrine
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  • Ibrutinib
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  • Linezolid
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  • Loratadine; Pseudoephedrine
  • Lorcaserin
  • Lorlatinib
  • Losartan
  • Lovastatin
  • Lovastatin; Niacin
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Lumateperone
  • Lurasidone
  • Macimorelin
  • Macitentan
  • Maraviroc
  • Mefloquine
  • Meperidine
  • Meperidine; Promethazine
  • Mestranol; Norethindrone
  • Metformin; Repaglinide
  • Methadone
  • Methamphetamine
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methohexital
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