Sodium Fluoride F 18

What is Sodium Fluoride F 18

Sodium fluoride F 18 is an intravenous, radioactive, diagnostic agent used with positron emission tomography (PET) to define areas of altered osteogenic activity.

Once administered, the fluoride F 18 ion rapidly distributes to the skeleton, and is preferentially bound to areas of newly mineralized bone.

As fluoride F 18 decays, gamma photons are emitted which are detected by positron emission tomography (PET) imaging and identify areas of altered osteogenic activity, as observed during growth, infection, malignancy (primary and metastatic), following trauma, or inflammation of bone. Sodium fluoride F 18 was FDA-approved in January 2011.

Indications

• positron emission tomography (PET) imaging

For use during positron emission tomography (PET) imaging of bone to define areas of altered osteogenic activity

Side Effects

Sodium fluoride F 18 may increase the risk of developing a new primary malignancy. Carcinogenic and mutagenic studies have not been performed with sodium fluoride F 18. Use the lowest effective dose necessary, and ensure safe handling to protect the patient and health care provider.⁶⁰⁵¹³

Allergic and anaphylactoid reactions may occur following sodium fluoride F 18 administration. Emergency resuscitation equipment and personnel should be readily available.

Monitoring Parameters

• pregnancy testing

Contraindications

• accidental exposure
• breast-feeding
• children
• infants
• neonates
• new primary malignancy
• pregnancy
• pregnancy testing
• radiation exposure
• reproductive risk

Interactions

No information is available regarding drug interactions associated with Sodium Fluoride F 18