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What is Sodium Ferric Gluconate Complex ferric pyrophosphate citrate
Sodium ferric gluconate complex is an injectable iron replacement product indicated for the treatment of iron-deficiency anemia in adults and pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. Undiluted sodium ferric gluconate complex may be given without a test dose.
Ferric pyrophosphate citrate is an iron solution for addition to bicarbonate dialysate for the replacement of iron to maintain hemoglobin in adult patients with hemodialysis-dependent chronic kidney disease.
Parenteral iron is preferred over oral iron therapy when rapid repletion of iron-depleted patients is desired. A retrospective analysis of reported adverse medication events indicated a significantly lower mortality rate (p less than 0.001) with the use of sodium ferric gluconate complex compared to iron dextran.
Brand Name
- Ferrlecit
- Nulecit
- Triferic
Indications & Dosage
- iron-deficiency anemia
For the treatment of iron-deficiency anemia
For the treatment of iron-deficiency anemia in patients undergoing chronic hemodialysis who are receiving supplemental epoetin alfa therapy
Side Effects
- abdominal pain
- agitation
- anaphylactoid reactions
- anemia
- angina
- angioedema
- anorexia
- arthralgia
- asthenia
- back pain
- bleeding
- bradycardia
- bronchospasm
- cardiac arrest
- chest pain (unspecified)
- chills
- conjunctivitis
- constipation
- cough
- cyanosis
- diaphoresis
- diarrhea
- diplopia
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dyspnea
- edema
- eructation
- fatigue
- fever
- flank pain
- flatulence
- flushing
- headache
- hearing loss
- hemosiderosis
- hyperhidrosis
- hyperkalemia
- hypertension
- hypertonia
- hyperventilation
- hypervolemia
- hypoesthesia
- hypoglycemia
- hypokalemia
- hypotension
- infection
- injection site reaction
- leukocytosis
- lymphadenopathy
- malaise
- melena
- menorrhagia
- metabolic acidosis
- muscle cramps
- musculoskeletal pain
- myalgia
- myocardial infarction
- nausea
- pallor
- paresthesias
- peripheral edema
- peripheral vasodilation
- pharyngitis
- phlebitis
- pruritus
- pulmonary edema
- rhinitis
- seizures
- sinus tachycardia
- skin discoloration
- syncope
- thrombosis
- urticaria
- vomiting
- weakness
- wheezing
- xerostomia
Monitoring Parameters
- ferritin
- hemoglobin/hematocrit
- serum iron
- transferrin
Contraindications
- benzyl alcohol hypersensitivity
- breast-feeding
- cardiac disease
- children
- contraception requirements
- geriatric
- hemochromatosis
- hemoglobinopathy
- hemosiderosis
- hepatic disease
- hypotension
- infants
- intramuscular administration
- neonates
- pregnancy
- reproductive risk
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Acetohydroxamic Acid
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Antacids
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Omeprazole
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bisphosphonates
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Cefdinir
- Cholestyramine
- Cimetidine
- Ciprofloxacin
- Darbepoetin Alfa
- Deferasirox
- Deferiprone
- Deferoxamine
- Delafloxacin
- Dexlansoprazole
- Didanosine, ddI
- Dimercaprol
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Eltrombopag
- Epoetin Alfa
- Esomeprazole
- Esomeprazole; Naproxen
- Famotidine
- Famotidine; Ibuprofen
- Ferric carboxymaltose
- Ferumoxytol
- Gemifloxacin
- Green Tea
- H2-blockers
- Hydrochlorothiazide, HCTZ; Methyldopa
- Ibritumomab Tiuxetan
- Iron – Injectable Only
- Iron Dextran
- Iron Sucrose, Sucroferric Oxyhydroxide
- Lansoprazole
- Lansoprazole; Naproxen
- Lanthanum Carbonate
- Levodopa
- Levofloxacin
- Methoxy polyethylene glycol-epoetin beta
- Methyldopa
- Moxifloxacin
- Mycophenolate
- Nizatidine
- Norfloxacin
- Ofloxacin
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Pantoprazole
- Penicillamine
- Phosphorated Carbohydrate Solution
- Phosphorus
- Potassium Phosphate
- Potassium Phosphate; Sodium Phosphate
- Proton pump inhibitors
- Rabeprazole
- Ranitidine
- Sodium Bicarbonate
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Tetracyclines
- Thyroid hormones
- Trientine
- Zinc
