Simeprevir

What is Simeprevir

Simeprevir is an NS3/4A protease inhibitor, indicated for the treatment of genotype 1 and 4 chronic hepatitis C virus (HCV) infection in adults greater than or equal to 18 years of age. 

Brand Name

Olysio

Indications

• hepatitis C infection
• hepatitis C virus

Side Effects

• diarrhea
• dizziness
• dyspnea
• fatigue
• headache
• hepatic failure
• hepatitis B exacerbation
• hyperamylasemia
• hyperbilirubinemia
• myalgia
• nausea
• photosensitivity
• pruritus
• rash

Monitoring Parameters

• hepatitis B serology
• LFTs
• plasma hepatitis C RNA
• plasma HIV RNA
• pregnancy testing
• serum bilirubin (total and direct)

Contraindications

• anticoagulant therapy
• Asian patients
• breast-feeding
• children
• hepatic disease
• hepatitis B exacerbation
• hepatitis C and HIV coinfection
• infants
• liver transplant
• male-mediated teratogenicity
• neonates
• pregnancy
• serious rash
• sulfonamide hypersensitivity
• sunlight (UV) exposure

Interactions

• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Tramadol
• Afatinib
• Aldesleukin, IL-2
• Alfentanil
• Alfuzosin
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Valsartan
• Almotriptan
• Alpelisib
• Alprazolam
• Amiodarone
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Apalutamide
• Aprepitant, Fosaprepitant
• Aripiprazole
• Armodafinil
• Artemether; Lumefantrine
• Asenapine
• Aspirin, ASA; Oxycodone
• Aspirin, ASA; Pravastatin
• Atazanavir
• Atazanavir; Cobicistat
• Atorvastatin
• Atorvastatin; Ezetimibe
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Bendamustine
• Benzhydrocodone; Acetaminophen
• Betrixaban
• Bexarotene
• Boceprevir
• Bortezomib
• Bosentan
• Bosutinib
• Brigatinib
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Budesonide
• Budesonide; Formoterol
• Bupivacaine
• Bupivacaine Liposomal
• Bupivacaine; Lidocaine
• Buprenorphine
• Buprenorphine; Naloxone
• Buspirone
• Cabozantinib
• Caffeine; Ergotamine
• Carbamazepine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carvedilol
• Ceritinib
• Cerivastatin
• Cevimeline
• Chloramphenicol
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Cilostazol
• Cimetidine
• Cinacalcet
• Cisapride
• Citalopram
• Clarithromycin
• Clomipramine
• Clonazepam
• Clozapine
• Cobicistat
• Cobimetinib
• Colchicine
• Colchicine; Probenecid
• Conivaptan
• Crizotinib
• Cyclophosphamide
• Cyclosporine
• Dabigatran
• Daclatasvir
• Danazol
• Dapsone
• Darifenacin
• Darunavir
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Delavirdine
• Dexamethasone
• Dexlansoprazole
• Dextromethorphan; Quinidine
• Diazepam
• Diclofenac
• Diclofenac; Misoprostol
• Digoxin
• Dihydroergotamine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Disopyramide
• Disulfiram
• Docetaxel
• Dolasetron
• Donepezil
• Donepezil; Memantine
• Doravirine; Lamivudine; Tenofovir disoproxil fumarate
• Doxorubicin
• Dronedarone
• Dutasteride; Tamsulosin
• Edoxaban
• Efavirenz
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elagolix
• Elagolix; Estradiol; Norethindrone acetate
• Elbasvir; Grazoprevir
• Eletriptan
• Eliglustat
• Eluxadoline
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Emtricitabine; Tenofovir disoproxil fumarate
• Enalapril; Felodipine
• Enzalutamide
• Eplerenone
• Ergotamine
• Erlotinib
• Erythromycin
• Erythromycin; Sulfisoxazole
• Escitalopram
• Eslicarbazepine
• Estazolam
• Eszopiclone
• Ethosuximide
• Etravirine
• Ezetimibe; Simvastatin
• Fedratinib
• Felbamate
• Felodipine
• Fentanyl
• Flecainide
• Flibanserin
• Fluconazole
• Fluoxetine
• Fluoxetine; Olanzapine
• Flurazepam
• Flutamide
• Fluvastatin
• Fluvoxamine
• Fosamprenavir
• Fosphenytoin
• Fostamatinib
• Gemfibrozil
• Glecaprevir; Pibrentasvir
• Glyburide
• Glyburide; Metformin
• grapefruit juice
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Haloperidol
• Homatropine; Hydrocodone
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Ibuprofen; Oxycodone
• Idelalisib
• Imatinib
• Imipramine
• Indacaterol
• Indacaterol; Glycopyrrolate
• Indinavir
• Isavuconazonium
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Isradipine
• Itraconazole
• Ivabradine
• Ixabepilone
• Ketoconazole
• Lamivudine; Tenofovir Disoproxil Fumarate
• Lapatinib
• Ledipasvir; Sofosbuvir
• Lefamulin
• Lemborexant
• Letermovir
• Lidocaine
• Loperamide
• Loperamide; Simethicone
• Lopinavir; Ritonavir
• Lorlatinib
• Lovastatin
• Lovastatin; Niacin
• Lumacaftor; Ivacaftor
• Lurasidone
• Maraviroc
• Mefloquine
• Metformin; Repaglinide
• Methadone
• Methotrexate
• Mexiletine
• Midazolam
• Mifepristone
• Milk Thistle, Silybum marianum
• Mitotane
• Mitoxantrone
• Modafinil
• Morphine
• Morphine; Naltrexone
• Naldemedine
• Nebivolol; Valsartan
• Nefazodone
• Nelfinavir
• Neratinib
• Nevirapine
• Niacin; Simvastatin
• Nicardipine
• Nifedipine
• Nimodipine
• Nintedanib
• Nisoldipine
• Obeticholic Acid
• Octreotide
• Olanzapine
• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole; Amoxicillin; Rifabutin
• Oritavancin
• Osimertinib
• Oxcarbazepine
• Oxybutynin
• Oxycodone
• Paclitaxel
• Paricalcitol
• Pazopanib
• Perampanel
• Perindopril; Amlodipine
• Perphenazine; Amitriptyline
• Phenobarbital
• Phentermine; Topiramate
• Phenytoin
• Pimozide
• Pitavastatin
• Porfimer
• Posaconazole
• Pravastatin
• Prednisolone
• Prednisone
• Primidone
• Propafenone
• Quazepam
• Quetiapine
• Quinidine
• Quinine
• Ramelteon
• Ranolazine
• Rasagiline
• Repaglinide
• Revefenacin
• Ribociclib
• Ribociclib; Letrozole
• Rifabutin
• Rifampin
• Rifamycins
• Rifapentine
• Rifaximin
• Ritonavir
• Rivaroxaban
• Ropinirole
• Ropivacaine
• Rosuvastatin
• Sacubitril; Valsartan
• Sapropterin
• Saquinavir
• Sertraline
• Sibutramine
• Sildenafil
• Silodosin
• Simvastatin
• Simvastatin; Sitagliptin
• Sirolimus
• Sofosbuvir
• Sofosbuvir; Velpatasvir
• Sofosbuvir; Velpatasvir; Voxilaprevir
• Solifenacin
• Sorafenib
• St. John’s Wort, Hypericum perforatum
• Sufentanil
• Sulfasalazine
• Tadalafil
• Tamsulosin
• Telithromycin
• Telotristat Ethyl
• Temsirolimus
• Teniposide
• Tenofovir Alafenamide
• Tenofovir, PMPA
• Teriflunomide
• Theophylline, Aminophylline
• Thiabendazole
• Tiagabine
• Ticagrelor
• Tinidazole
• Tipranavir
• Tizanidine
• Tolterodine
• Topiramate
• Topotecan
• Tramadol
• Trandolapril; Verapamil
• Trazodone
• Triamterene
• Triazolam
• Ubrogepant
• Valsartan
• Vemurafenib
• Venetoclax
• Verapamil
• Verteporfin
• Vinblastine
• Vincristine
• Vincristine Liposomal
• Vinorelbine
• Vorapaxar
• Voriconazole
• Warfarin
• Zafirlukast
• Ziprasidone
• Zolpidem
• Zonisamide