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What is Selinexor
Selinexor is a nuclear export inhibitor.
It is indicated in combination with dexamethasone for the treatment of adult patients with relapsed or refractory multiple myeloma who have received at least 4 prior therapies and have refractory disease to at least 2 proteasome inhibitors, at least 2 immunomodulatory agents, and an anti-CD38 monoclonal antibody.
The FDA has granted selinexor accelerated approval and fast track status for this indication; further study is required to verify clinical benefit.
Brand Name
XPOVIO
Indications & Dosage
- multiple myeloma
For the treatment of multiple myeloma
NOTE: The FDA has designated selinexor as an orphan drug for the treatment of multiple myeloma.
for the treatment of multiple myeloma in patients who have received at least 4 prior therapies and who are refractory to at least 2 proteasome inhibitors, at least 2 immunomodulatory agents, and an anti-CD38 monoclonal antibody, in combination with dexamethasone
Side Effects
- anemia
- anemia
- anorexia
- anorexia
- asthenia
- asthenia
- bleeding
- blurred vision
- blurred vision
- confusion
- constipation
- constipation
- cough
- dehydration
- dehydration
- delirium
- diarrhea
- diarrhea
- dizziness
- dysgeusia
- dyspnea
- dyspnea
- epistaxis
- epistaxis
- fatigue
- fatigue
- fever
- fever
- headache
- hyperglycemia
- hyperglycemia
- hypokalemia
- hypokalemia
- hyponatremia
- hyponatremia
- infection
- infection
- influenza
- insomnia
- insomnia
- leukopenia
- leukopenia
- lymphopenia
- lymphopenia
- nausea
- nausea
- nephrotoxicity
- neurotoxicity
- neurotoxicity
- neutropenia
- neutropenia
- pharyngitis
- rhinitis
- syncope
- thrombocytopenia
- thrombocytopenia
- vomiting
- vomiting
- weight loss
- weight loss
Monitoring Parameters
- CBC with differential
- pregnancy testing
- serum electrolytes
- weight
Contraindications
- anemia
- bleeding
- breast-feeding
- contraception requirements
- dehydration
- diarrhea
- driving or operating machinery
- electrolyte imbalance
- geriatric
- hyponatremia
- infection
- infertility
- male-mediated teratogenicity
- nausea/vomiting
- neurotoxicity
- neutropenia
- pregnancy
- pregnancy testing
- reproductive risk
- thrombocytopenia
Interactions
There are no drug interactions associated with Selinexor products.
