S adenosyl L methionine SAM e

What is S adenosyl L methionine SAM e

S-adenosyl-L-methionine (SAM-e) is a naturally occurring molecule that is endogenous to humans; it is present in almost every tissue and fluid in the body. Synonyms for SAM-e include ademetionine, AdoMet, and S-adenosylmethionine. SAM-e is important in a variety of biochemical reactions involving enzymatic transmethylation.

The endogenous donation of methyl groups from SAM-e is important in the synthesis, activation and/or metabolism of a variety of other endogenous molecules such as hormones, nucleic acids, proteins, phospholipids, neurotransmitters, and some drugs


  • AIDS-associated myelopathy
  • Alzheimer’s disease
  • depression
  • fibromyalgia
  • hepatic cirrhosis
  • intrahepatic cholestasis of pregnancy (ICP)
  • nutritional supplementation
  • osteoarthritis

Side Effects

  • anorexia
  • anxiety
  • constipation
  • diaphoresis
  • diarrhea
  • dizziness
  • dyspepsia
  • emotional lability
  • fatigue
  • flatulence
  • headache
  • insomnia
  • mania
  • nausea
  • pseudoparkinsonism
  • suicidal ideation
  • vomiting
  • xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary


  • acquired immunodeficiency syndrome (AIDS)
  • bipolar disorder
  • breast-feeding
  • children
  • depression
  • ethanol intoxication
  • hepatic disease
  • hepatitis
  • infants
  • mania
  • migraine
  • neonates
  • neurological disease
  • neuromuscular disease
  • Parkinson’s disease
  • pregnancy
  • psychosis
  • seizure disorder
  • suicidal ideation


There are no drug interactions associated with S-adenosyl-L-methionine, SAM-e products.


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