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What is S adenosyl L methionine SAM e
S-adenosyl-L-methionine (SAM-e) is a naturally occurring molecule that is endogenous to humans; it is present in almost every tissue and fluid in the body. Synonyms for SAM-e include ademetionine, AdoMet, and S-adenosylmethionine. SAM-e is important in a variety of biochemical reactions involving enzymatic transmethylation.
The endogenous donation of methyl groups from SAM-e is important in the synthesis, activation and/or metabolism of a variety of other endogenous molecules such as hormones, nucleic acids, proteins, phospholipids, neurotransmitters, and some drugs
Indications
- AIDS-associated myelopathy
- Alzheimer’s disease
- depression
- fibromyalgia
- hepatic cirrhosis
- intrahepatic cholestasis of pregnancy (ICP)
- nutritional supplementation
- osteoarthritis
Side Effects
- anorexia
- anxiety
- constipation
- diaphoresis
- diarrhea
- dizziness
- dyspepsia
- emotional lability
- fatigue
- flatulence
- headache
- insomnia
- mania
- nausea
- pseudoparkinsonism
- suicidal ideation
- vomiting
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- acquired immunodeficiency syndrome (AIDS)
- bipolar disorder
- breast-feeding
- children
- depression
- ethanol intoxication
- hepatic disease
- hepatitis
- infants
- mania
- migraine
- neonates
- neurological disease
- neuromuscular disease
- Parkinson’s disease
- pregnancy
- psychosis
- seizure disorder
- suicidal ideation
Interactions
There are no drug interactions associated with S-adenosyl-L-methionine, SAM-e products.
