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What is Rufinamide
Rufinamide is a triazole derivative that is unrelated to currently marketed anticonvulsants.
Although rufinamide is only FDA-approved for use in Lennox-Gastaut syndrome, clinical trial data indicate the drug may also be beneficial as adjunctive treatment of refractory partial seizures.
Rufinamide was FDA-approved in November 2008 with an orphan drug designation for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome in children 4 years and older and adults.
In February 2015, this indication was expanded to include children as young as 1 year of age.
Brand Name
Banzel
Indications
- Lennox-Gastaut syndrome
- partial seizures
Side Effects
- abdominal pain
- anemia
- anorexia
- anxiety
- appetite stimulation
- ataxia
- AV block
- back pain
- blurred vision
- bundle-branch block
- constipation
- cough
- diplopia
- dizziness
- drowsiness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dyspepsia
- dysuria
- fatigue
- headache
- hematuria
- infection
- infertility
- influenza
- leukopenia
- lymphadenopathy
- nasal congestion
- nausea
- nephrolithiasis
- neutropenia
- nocturia
- nystagmus
- pharyngitis
- polyuria
- pruritus
- rash
- seizures
- sinusitis
- Stevens-Johnson syndrome
- suicidal ideation
- thrombocytopenia
- tremor
- urinary incontinence
- vertigo
- vomiting
- weight loss
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- breast-feeding
- depression
- dialysis
- driving or operating machinery
- geriatric
- hepatic disease
- infertility
- pregnancy
- reproductive risk
- short QT syndrome
- shortened QT interval
- suicidal ideation
Interactions
- Alprazolam
- Amiodarone
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamines
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzhydrocodone; Acetaminophen
- Benzphetamine
- Bepridil
- Bortezomib
- Buprenorphine
- Buprenorphine; Naloxone
- Busulfan
- Caffeine; Ergotamine
- Cannabidiol
- Carbamazepine
- Cenobamate
- Cevimeline
- Chlorzoxazone
- Cilostazol
- Cisapride
- Cyclosporine
- Dapsone
- Deutetrabenazine
- Dextroamphetamine
- Dextromethorphan; Quinidine
- Dihydroergotamine
- Docetaxel
- Donepezil
- Donepezil; Memantine
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Ethanol
- Ethosuximide
- Fosphenytoin
- Hydroxychloroquine
- Imatinib
- Isavuconazonium
- Lacosamide
- Lamotrigine
- Levobupivacaine
- Lisdexamfetamine
- Macimorelin
- Methamphetamine
- Methylergonovine
- Methysergide
- Midazolam
- Molindone
- Nefazodone
- Non-oral combination contraceptives
- Oral Contraceptives
- Paclitaxel
- Paricalcitol
- Pergolide
- Phenobarbital
- Phentermine; Topiramate
- Phenytoin
- Primidone
- Quinidine
- Quinine
- Remdesivir
- Sibutramine
- Sirolimus
- Tacrolimus
- Telithromycin
- Terfenadine
- Topiramate
- Triazolam
- Tricyclic antidepressants
- Trimetrexate
- Valproic Acid, Divalproex Sodium
- Zolpidem
- Zonisamide
