Romidepsin

What is Romidepsin

Romidepsin is a histone deacetylase (HDAC) inhibitor that is indicated for the treatment of cutaneous T-cell lymphoma and peripheral T-cell lymphoma in patients who have received at least 1 prior systemic treatment.

Electrocardiogram abnormalities including QT interval prolongation have been reported; ensure potassium and magnesium levels are within normal range before administering therapy.

Brand Name

Istodax

Indications

• cutaneous T-cell lymphoma (CTCL)
• peripheral T-cell lymphoma (PTCL)

For the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least 1 prior systemic therapy

Side Effects

1. abdominal pain
2. acute respiratory distress syndrome (ARDS)
3. anemia
4. anemia
5. anorexia
6. anorexia
7. arrhythmia exacerbation
8. asthenia
9. asthenia
10. chest pain (unspecified)
11. chills
12. constipation
13. constipation
14. cough
15. dehydration
16. diarrhea
17. diarrhea
18. dysgeusia
19. dyspnea
20. dyspnea
21. edema
22. elevated hepatic enzymes
23. elevated hepatic enzymes
24. exfoliative dermatitis
25. fatigue
26. fatigue
27. fever
28. fever
29. headache
30. headache
31. heart failure
32. hepatic failure
33. hepatitis
34. hyperbilirubinemia
35. hyperglycemia
36. hyperglycemia
37. hypermagnesemia
38. hypermagnesemia
39. hyperuricemia
40. hyperuricemia
41. hypoalbuminemia
42. hypoalbuminemia
43. hypocalcemia
44. hypocalcemia
45. hypokalemia
46. hypokalemia
47. hypomagnesemia
48. hypomagnesemia
49. hyponatremia
50. hyponatremia
51. hypophosphatemia
52. hypophosphatemia
53. hypotension
54. hypotension
55. hypoxia
56. infection
57. infection
58. infertility
59. leukopenia
60. leukopenia
61. lymphopenia
62. lymphopenia
63. nausea
64. nausea
65. neutropenia
66. neutropenia
67. peripheral edema
68. pneumonitis
69. pruritus
70. pulmonary embolism
71. QT prolongation
72. renal failure (unspecified)
73. sinus tachycardia
74. ST-T wave changes
75. stomatitis
76. syncope
77. thrombocytopenia
78. thrombocytopenia
79. thrombosis
80. tumor lysis syndrome (TLS)
81. vomiting
82. vomiting
83. weight loss

Monitoring Parameters

• CBC with differential
• LFTs
• pregnancy testing
• serum creatinine/BUN
• serum electrolytes
• serum uric acid

Contraindications

• alcoholism
• anemia
• bradycardia
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• contraception requirements
• coronary artery disease
• diabetes mellitus
• females
• geriatric
• heart failure
• hepatic disease
• hepatitis
• hypertension
• hypocalcemia
• hypokalemia
• hypomagnesemia
• infection
• infertility
• leukopenia
• long QT syndrome
• male-mediated teratogenicity
• malnutrition
• myocardial infarction
• neutropenia
• pregnancy
• pregnancy testing
• QT prolongation
• reproductive risk
• thrombocytopenia
• thyroid disease
• tumor lysis syndrome (TLS)
• viral infection

Interactions

• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Aclidinium; Formoterol
• Albuterol
• Albuterol; Ipratropium
• Aldesleukin, IL-2
• Alfuzosin
• Amiodarone
• Amobarbital
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Amprenavir
• Anagrelide
• Apalutamide
• Apomorphine
• Aprepitant, Fosaprepitant
• Arformoterol
• Aripiprazole
• Arsenic Trioxide
• Artemether; Lumefantrine
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Atazanavir
• Atazanavir; Cobicistat
• Atomoxetine
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azithromycin
• Bedaquiline
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Bexarotene
• Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Boceprevir
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• Brigatinib
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• Butabarbital
• Cabozantinib
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• Ciprofloxacin
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• Codeine; Promethazine
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