Role of prophylactic antibiotics in Reactive Arthritis
Should you use prophylactic antibiotics in Reactive Arthritis patients?
Prophylactic antibiotics should be considered in patients with a previous episode of ReA who later develop urethritis after unprotected sex or traveler’s diarrhea. Azithromycin (1 g) as a single dose for urethritis, or azithromycin (1 g) as a single dose ( Campylobacter ) plus ciprofloxacin (750 mg) as a single dose ( Salmonella , Shigella , and Yersinia ) at onset of diarrhea has anecdotally prevented the subsequent redevelopment of ReA. Probiotics should be used in patients with a history of ReA due to C. Difficile when antibiotics must be used.
