Role of prophylactic antibiotics in Reactive Arthritis

Role of prophylactic antibiotics in Reactive Arthritis

Should you use prophylactic antibiotics in Reactive Arthritis patients?

Prophylactic antibiotics should be considered in patients with a previous episode of ReA who later develop urethritis after unprotected sex or traveler’s diarrhea. Azithromycin (1 g) as a single dose for urethritis, or azithromycin (1 g) as a single dose ( Campylobacter ) plus ciprofloxacin (750 mg) as a single dose ( Salmonella , Shigella , and Yersinia ) at onset of diarrhea has anecdotally prevented the subsequent redevelopment of ReA. Probiotics should be used in patients with a history of ReA due to C. Difficile when antibiotics must be used.

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