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What is Ripretinib
Ripretinib is a tyrosine kinase inhibitor that works in many mutant KIT and PDGFRA kinases found in tumor cells.
It is indicated for the treatment of adult patients with advanced gastrointestinal stromal tumor (GIST) who have received prior treatment with 3 or more kinase inhibitors, including imatinib.
Cardiac dysfunction (e.g., decreased ejection fraction and heart failure) has been reported; evaluate cardiac function prior to and during therapy as clinically indicated.
Brand Name
QINLOCK
Indications
- gastrointestinal stromal tumors (GIST)
Side Effects
- abdominal pain
- alopecia
- anemia
- anorexia
- arthralgia
- asthenia
- cardiac arrest
- cardiotoxicity
- constipation
- diarrhea
- dyspnea
- elevated hepatic enzymes
- fatigue
- headache
- heart failure
- hyperamylasemia
- hyperbilirubinemia
- hypertension
- hypertriglyceridemia
- hypocalcemia
- hyponatremia
- hypophosphatemia
- muscle cramps
- myalgia
- myocardial infarction
- nausea
- nephrotoxicity
- neutropenia
- new primary malignancy
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- peripheral edema
- prolonged bleeding time
- pruritus
- skin cancer
- stomatitis
- vomiting
- weight loss
- xerosis
Monitoring Parameters
- blood pressure
- ejection fraction
- pregnancy testing
- skin cancer screening exam
Contraindications
- arthralgia
- breast-feeding
- cardiac disease
- contraception requirements
- hypertension
- impaired wound healing
- infertility
- male-mediated teratogenicity
- new primary malignancy
- pregnancy
- pregnancy testing
- reproductive risk
- serious rash
- surgery
Interactions
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Carbamazepine
- Ceritinib
- Chloramphenicol
- Clarithromycin
- Cobicistat
- Conivaptan
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Fosphenytoin
- grapefruit juice
- Idelalisib
- Indinavir
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Lopinavir; Ritonavir
- Mifepristone
- Mitotane
- Nefazodone
- Nelfinavir
- Ombitasvir; Paritaprevir; Ritonavir
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Ribociclib
- Ribociclib; Letrozole
- Rifampin
- Ritonavir
- Saquinavir
- St. John’s Wort, Hypericum perforatum
- Telithromycin
- Tipranavir
- Tucatinib
- Voriconazole
