Rilpivirine

What is Rilpivirine

Rilpivirine is an oral, diarylpyrimidine, non-nucleoside reverse transcriptase inhibitor (NNRTI).

It is indicated for use with other antiretroviral agents to treat HIV-1 infection in antiretroviral treatment-naive patients 12 years and older and weight at least 35 kg with HIV-1 RNA concentrations of 100,000 copies/mL or less at initiation of therapy. 

Brand Name

EDURANT

Indications

1. human immunodeficiency virus (HIV)
2. human immunodeficiency virus (HIV) infection
3. human immunodeficiency virus (HIV) prophylaxis

Side Effects

1. abdominal pain
2. abnormal dreams
3. adrenocortical insufficiency
4. anxiety
5. breast enlargement
6. cholecystitis
7. cholelithiasis
8. Cushingoid features
9. depression
10. depression
11. diarrhea
12. dizziness
13. drowsiness
14. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
15. dysphoria
16. elevated hepatic enzymes
17. fatigue
18. glomerulonephritis
19. gynecomastia
20. headache
21. hyperbilirubinemia
22. hypercholesterolemia
23. hypertriglyceridemia
24. insomnia
25. lipodystrophy
26. nausea
27. nephrolithiasis
28. nephrotic syndrome
29. rash
30. suicidal ideation
31. vomiting

Monitoring Parameters

• blood glucose
• CBC with differential
• CD4+ T cell count
• hepatitis B serology
• LFTs
• plasma hepatitis C RNA
• plasma HIV RNA
• pregnancy testing
• serum bilirubin (total and direct)
• serum cholesterol
• serum creatinine
• serum lipid profile
• urinalysis

Contraindications

• alcoholism
• autoimmune disease
• bradycardia
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• children
• coronary artery disease
• depression
• diabetes mellitus
• females
• geriatric
• Graves’ disease
• Guillain-Barre syndrome
• heart failure
• hepatic disease
• hepatitis B and HIV coinfection
• hepatitis C and HIV coinfection
• human immunodeficiency virus (HIV) infection resistance
• hypercholesterolemia
• hyperlipidemia
• hypertension
• hypertriglyceridemia
• hypocalcemia
• hypokalemia
• hypomagnesemia
• immune reconstitution syndrome
• infants
• long QT syndrome
• malnutrition
• myocardial infarction
• neonates
• pregnancy
• QT prolongation
• serious rash
• suicidal ideation
• thyroid disease

Interactions

• Abarelix
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Aclidinium; Formoterol
• Adefovir
• Albuterol
• Albuterol; Ipratropium
• Aldesleukin, IL-2
• Alfuzosin
• Amiodarone
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amobarbital
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Anagrelide
• Antacids
• Apalutamide
• Apomorphine
• Aprepitant, Fosaprepitant
• Arformoterol
• Aripiprazole
• Armodafinil
• Arsenic Trioxide
• Artemether; Lumefantrine
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
• Aspirin, ASA; Omeprazole
• Atazanavir
• Atazanavir; Cobicistat
• Atomoxetine
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azithromycin
• Bedaquiline
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Bepridil
• Bexarotene
• Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Boceprevir
• Bosentan
• Budesonide; Formoterol
• Buprenorphine
• Buprenorphine; Naloxone
• Butabarbital
• Calcium Carbonate
• Calcium Carbonate; Magnesium Hydroxide
• Calcium Carbonate; Risedronate
• Calcium Carbonate; Simethicone
• Carbamazepine
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• Elagolix
• Elagolix; Estradiol; Norethindrone acetate
• Eliglustat
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• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Encorafenib
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• Eribulin
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• Esomeprazole; Naproxen
• Etravirine
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• Famotidine; Ibuprofen
• Fedratinib
• Fingolimod
• Flecainide
• Fluconazole
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluphenazine
• Flutamide
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Fluvoxamine
• food
• Formoterol
• Formoterol; Mometasone
• Fosamprenavir
• Foscarnet
• Fosphenytoin
• Gemifloxacin
• Gemtuzumab Ozogamicin
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• Glycopyrrolate; Formoterol
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• Halofantrine
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• Indinavir
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• Interferon Alfa-2a
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• Interferon Alfa-2b; Ribavirin
• Interferon Alfa-n3
• Interferon Alfacon-1
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• Interferon Gamma-1b
• Interferons
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