What is Rayos?
Rayos is the brand name of delayed-release prednisone tablets (1, 2, and 5 mg). Compared with immediate-release prednisone, it has a formulation that results in a 4-hour lag time for its release. Otherwise its mode of action and pharmacokinetics are identical to immediate-release prednisone. Rayos is administered at 10:00 p.m. and prednisone is released during the night when cytokine release is increased. This allows for improved symptoms in the morning. It is primarily for use in patients with rheumatoid arthritis, polymyalgia rheumatica, asthma, and chronic obstructive pulmonary disease. The average retail cost is $3100/month (#30, 5-mg tablets) compared with $10 to $30/month immediate-release prednisone (#30, 5-mg tablets).