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What is Ramipril
Ramipril is an oral angiotensin-converting enzyme (ACE) inhibitor used in the treatment of hypertension.
Ramipril is an inactive prodrug that is converted in the liver to ramiprilat, the active moiety.
Ramipril is dosed once or twice daily for the treatment of hypertension.
Brand Name
Altace
Indications & Dosage
- diabetic nephropathy
- heart failure
- hypertension
- myocardial infarction prophylaxis
- persistent albuminuria
- postmyocardial infarction
- reduction of cardiovascular mortality
- stroke prophylaxis
For reduction of cardiovascular mortality, myocardial infarction (myocardial infarction prophylaxis) and stroke (stroke prophylaxis) in adults 55 years or older who are at high risk of developing major cardiovascular events
Side Effects
- abdominal pain
- agranulocytosis
- amnesia
- anaphylactoid reactions
- angina
- angioedema
- anorexia
- anxiety
- arthralgia
- asthenia
- azotemia
- cholestasis
- constipation
- cough
- depression
- diarrhea
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dysphagia
- dyspnea
- edema
- elevated hepatic enzymes
- eosinophilia
- eosinophilic pneumonia
- epistaxis
- erythema multiforme
- fatigue
- fever
- headache
- hearing loss
- hemolytic anemia
- hepatic failure
- hepatic necrosis
- hepatitis
- hyperkalemia
- hypersalivation
- hypoglycemia
- hyponatremia
- hypotension
- impotence (erectile dysfunction)
- insomnia
- jaundice
- leukopenia
- malaise
- myalgia
- nausea
- neuropathic pain
- oliguria
- onycholysis
- orthostatic hypotension
- palpitations
- pancreatitis
- pancytopenia
- paresthesias
- pemphigus
- photosensitivity
- proteinuria
- pruritus
- purpura
- rash
- renal failure (unspecified)
- Stevens-Johnson syndrome
- syncope
- teratogenesis
- thrombocytopenia
- tinnitus
- toxic epidermal necrolysis
- tremor
- urticaria
- vasculitis
- vertigo
- visual impairment
- vomiting
- weight gain
- xerostomia
Monitoring Parameters
- blood pressure
- serum creatinine/BUN
- serum potassium
- serum sodium
Contraindications
- ACE-inhibitor induced angioedema
- angioedema
- Angiotensin-converting enzyme inhibitors (ACE inhibitors) hypersensitivity
- aortic stenosis
- autoimmune disease
- Black patients
- bone marrow suppression
- breast-feeding
- cardiomyopathy
- cerebrovascular disease
- collagen-vascular disease
- coronary artery disease
- diabetes mellitus
- dialysis
- geriatric
- heart failure
- hepatic disease
- hereditary angioedema
- hymenoptera venom (insect sting) allergy desensitization
- hyperkalemia
- hyponatremia
- hypotension
- hypovolemia
- immunosuppression
- infants
- jaundice
- low-density lipoprotein apheresis
- neonates
- pregnancy
- renal artery stenosis
- renal disease
- renal failure
- renal impairment
- scleroderma
- systemic lupus erythematosus (SLE)
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alemtuzumab
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alogliptin; Metformin
- Alpha-glucosidase Inhibitors
- Alprostadil
- Amifostine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amphetamine; Dextroamphetamine Salts
- Amyl Nitrite
- Angiotensin II
- Angiotensin II receptor antagonists
- Apomorphine
- Apraclonidine
- Aprotinin
- Aripiprazole
- Asenapine
- Azathioprine
- Azilsartan
- Azilsartan; Chlorthalidone
- Baclofen
- Benzphetamine
- Bosentan
- Brexpiprazole
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Cabergoline
- Calcium Phosphate, Supersaturated
- Canagliflozin; Metformin
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carvedilol
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloroprocaine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Clozapine
- Co-Enzyme Q10, Ubiquinone
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Conivaptan
- Cyclophosphamide
- Cyclosporine
- Dapagliflozin; Metformin
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diazoxide
- Diethylpropion
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enflurane
- Entecavir
- Ephedrine
- Eplerenone
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ertugliflozin; Metformin
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Etomidate
- Everolimus
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Fluorescein
- Fluoxetine; Olanzapine
- Fospropofol
- General anesthetics
- Glipizide; Metformin
- Glyburide; Metformin
- Gold
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Haloperidol
- Halothane
- Heparin
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen; Pseudoephedrine
- Icatibant
- Iloperidone
- Iloprost
- Incretin Mimetics
- Indapamide
- Insulins
- Intravenous Lipid Emulsions
- Iohexol
- Iopamidol
- Iopromide
- Ioversol
- Irbesartan
- Iron Dextran
- Isocarboxazid
- Isoflurane
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Isosulfan Blue
- Kanamycin
- Ketamine
- Lanthanum Carbonate
- Levodopa
- Linagliptin; Metformin
- Lisdexamfetamine
- Lithium
- Loop diuretics
- Loratadine; Pseudoephedrine
- Losartan
- Lovastatin; Niacin
- Lurasidone
- Magnesium Salts
- Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
- Meglitinides
- Mestranol; Norethindrone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methamphetamine
- Methohexital
- Methylphenidate
- Milrinone
- Naproxen; Pseudoephedrine
- Nateglinide
- Nebivolol; Valsartan
- Nefazodone
- Nesiritide, BNP
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nitrates
- Nitroglycerin
- Nitroprusside
- Non-Ionic Contrast Media
- Nonsteroidal antiinflammatory drugs
- Olanzapine
- Olmesartan
- Oxymetazoline
- Paliperidone
- Pentoxifylline
- Phenelzine
- Phenylephrine
- Phenylephrine; Promethazine
- Polyethylene Glycol; Electrolytes
- Polyethylene Glycol; Electrolytes; Ascorbic Acid
- Potassium
- Pramlintide
- Prazosin
- Pregabalin
- Procainamide
- Procaine
- Propofol
- Pseudoephedrine
- Quinidine
- Rasagiline
- Repaglinide
- Risperidone
- Sacubitril; Valsartan
- Salicylates
- Selegiline
- Sevoflurane
- SGLT2 Inhibitors
- Silodosin
- Sirolimus
- Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Spironolactone
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfonylureas
- Tacrolimus
- Telavancin
- Telbivudine
- Telmisartan
- Temsirolimus
- Tetrabenazine
- Tetracaine
- Thiazide diuretics
- Thiazolidinediones
- Thiopental
- Thiothixene
- Tizanidine
- Tolvaptan
- Tranylcypromine
- Trazodone
- Triamterene
- Trimethoprim
- Valsartan
- Yohimbine
- Ziprasidone
