NSAIDs to treat arthritis in childhood

NSAIDs to treat arthritis in childhood

Medication aDaily Dose (mg/kg/day)
Salicylate<25 kg: 80–100 divided three times a day
>25 kg: 2.5 g/m /day divided three times a day (max 4000 mg/day)
Choline magnesium trisalicylate50–65 divided twice a day (max 4500 mg/day)
Ibuprofen30–50 divided twice a day (max 3200 mg/day)
Naproxen (>2 years old)10–20 divided twice a day (max 1 g/day)
Indomethacin0.5–3 divided three times a day (max 150 mg/day); SR divided twice a day
Tolmetin (>2 years old)15–30 divided three times a day (max 1800 mg/day)
Meloxicam (>2 years old)0.125–0.25 daily (max 15 mg/day)
Etodolac SR (>6 years old)20–30 daily (max 1200 mg/day); 400 mg daily (wt 20–30 kg); 600 mg daily (31–45 kg); 800 mg daily (46–60 kg)
Oxaprozin (>6 years old)10–20 daily (max 1200 mg/day); 600 mg daily (wt 22–31 kg); 900 mg daily (wt 32–54 kg); 1200 mg daily (wt >55 kg)
Celecoxib (>2 years old)6–7 divided twice a day (max 400 mg/day); 50 mg twice a day (wt 10–25 kg); 100 mg twice a day (wt >25 kg)
Piroxicam0.25–0.45 daily (max 20 mg/day); 5–10 mg daily (wt <25 kg); 5–20 mg daily (wt >25 kg)
Sulindac4–6 divided twice a day (max 400 mg/day)
Nabumetone20–30 divided twice a day (max 2000 mg/day)
Diclofenac1–3 divided twice a day (max 150 mg/day)

FDA, Food and Drug Administration; JIA, juvenile idiopathic arthritis; SR, sustained release.

a The last four on the list (piroxicam, sulindac, nabumetone, and diclofenac) are not FDA-approved and have little safety data for use in children. Owing to the concern of possible Reye syndrome, salicylate is less often used, especially during the influenza season and varicella outbreaks. NSAIDs are also available in liquid form (naproxen, ibuprofen, meloxicam, and indomethacin), which are easier to administer to children aged <5 years. Naproxen, tolmetin meloxicam, and celecoxib are FDA-approved for JIA patients aged >2 years; ibuprofen is FDA-approved for JIA patients aged >12 years; indomethacin is FDA-approved for JIA patients aged >14 years.

15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top