Propafenone

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Propafenone Brand Names- Rythmol | Rythmol SR

What is Propafenone

Propafenone is an oral class IC antiarrhythmic agent which is used for the treatment of supraventricular arrhythmias and suppression of life-threatening ventricular arrhythmias.

Propafenone is similar mechanistically to encainide and flecainide, but is structurally similar to beta-blockers and possesses beta-blocking activity.

Propafenone is FDA-approved to treat symptomatic supraventricular arrhythmias or severe, life-threatening ventricular arrhythmias.

The IC antiarrhythmic agents have been shown to possess proarrhythmic characteristics during the CAST trials, which limits the use of these agents to prevent ventricular arrhythmias.

Propafenone is useful in pharmacologically convert atrial fibrillation to sinus rhythm, and to maintain sinus rhythm.

Propafenone therapy should be initiated in the hospital to allow for appropriate electrocardiographic (ECG) monitoring. Rythmol® (propafenone) was approved by the FDA in November 1989. Generic propafenone tablets became available in October 2000. Extended-release capsules (Rythmol® SR) were approved in September 2003.

Indications

  1. atrial fibrillation
  2. atrial flutter
  3. paroxysmal supraventricular tachycardia (PSVT) prophylaxis
  4. supraventricular arrhythmias
  5. ventricular tachycardia
  6. Wolff-Parkinson-White (WPW) syndrome

For the treatment of sustained ventricular tachycardia that is deemed to be life-threatening

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. alopecia
  4. amnesia
  5. anemia
  6. angina
  7. anorexia
  8. anxiety
  9. apnea
  10. arrhythmia exacerbation
  11. asystole
  12. ataxia
  13. atrial flutter
  14. AV block
  15. blurred vision
  16. bradycardia
  17. bundle-branch block
  18. cardiac arrest
  19. chest pain (unspecified)
  20. cholestasis
  21. coma
  22. confusion
  23. constipation
  24. cough
  25. dehydration
  26. depression
  27. diabetes mellitus
  28. diarrhea
  29. dizziness
  30. drowsiness
  31. dysgeusia
  32. dyspepsia
  33. dysphagia
  34. dyspnea
  35. dysuria
  36. ecchymosis
  37. edema
  38. elevated hepatic enzymes
  39. emotional lability
  40. epistaxis
  41. eructation
  42. erythema
  43. fatigue
  44. fever
  45. flatulence
  46. flushing
  47. gastroesophageal reflux
  48. GI obstruction
  49. glossitis
  50. glycosuria
  51. gout
  52. halitosis
  53. headache
  54. heart failure
  55. hematoma
  56. hematuria
  57. hemoptysis
  58. hepatitis
  59. hepatomegaly
  60. hot flashes
  61. hypercholesterolemia
  62. hyperglycemia
  63. hyperhidrosis
  64. hyperlipidemia
  65. hypertension
  66. hypertensive crisis
  67. hypertonia
  68. hypoesthesia
  69. hypokalemia
  70. hyponatremia
  71. hypotension
  72. impotence (erectile dysfunction)
  73. increased urinary frequency
  74. infection
  75. infertility
  76. influenza
  77. insomnia
  78. leukopenia
  79. libido decrease
  80. lymphadenopathy
  81. malaise
  82. mania
  83. melena
  84. memory impairment
  85. miosis
  86. muscle cramps
  87. muscle paralysis
  88. myalgia
  89. myocardial infarction
  90. nausea
  91. nephrotic syndrome
  92. nightmares
  93. nocturia
  94. ocular hemorrhage
  95. ocular inflammation
  96. ocular irritation
  97. oliguria
  98. oral ulceration
  99. pallor
  100. palpitations
  101. pancreatitis
  102. paresthesias
  103. peptic ulcer
  104. pericarditis
  105. peripheral neuropathy
  106. petechiae
  107. pleural effusion
  108. proteinuria
  109. pruritus
  110. psychosis
  111. ptosis
  112. purpura
  113. pyuria
  114. QT prolongation
  115. rash
  116. renal failure (unspecified)
  117. rhinitis
  118. seizures
  119. SIADH
  120. spermatogenesis inhibition
  121. syncope
  122. thrombocytopenia
  123. thrombosis
  124. tinnitus
  125. torsade de pointes
  126. tremor
  127. urinary incontinence
  128. urinary retention
  129. urticaria
  130. ventricular fibrillation
  131. ventricular tachycardia
  132. vertigo
  133. visual impairment
  134. vomiting
  135. weakness
  136. weight gain
  137. weight loss
  138. xerosis
  139. xerostomia

Monitoring Parameters

  • ECG

Contraindications

  • acute bronchospasm
  • alcoholism
  • asthma
  • AV block
  • bradycardia
  • breast-feeding
  • Brugada syndrome
  • cardiac arrhythmias
  • cardiac disease
  • cardiogenic shock
  • chronic obstructive pulmonary disease (COPD)
  • coronary artery disease
  • diabetes mellitus
  • electrolyte imbalance
  • females
  • geriatric
  • heart failure
  • hepatic disease
  • hyperkalemia
  • hypertension
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • hypotension
  • infertility
  • long QT syndrome
  • malnutrition
  • mortality
  • myasthenia gravis
  • myocardial infarction
  • neonates
  • pregnancy
  • QT prolongation
  • renal failure
  • renal impairment
  • sick sinus syndrome
  • systemic lupus erythematosus (SLE)
  • thyroid disease

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